Zoekresultaten - Klebe, Gerhard (Prof. Dr.)

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  1. 1
    Leitstruktursuche mithilfe eines kristallographischen Fragment-Screenings zur Inhibierung des Klasse-II-Chaperons IpgC aus Shigella flexneri

    Leitstruktursuche mithilfe eines kristallographischen Fragment-Screenings zur Inhibierung des Klasse-II-Chaperons IpgC aus Shigella flexneri door Gárdonyi, Marina

    Gepubliceerd in 2021
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  2. 2
    Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

    Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase door Sandner, Anna Sophie

    Gepubliceerd in 2022
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  3. 3
    Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the Road of Drug Design

    Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the... door Badran, Mohammed

    Gepubliceerd in 2021
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  4. 4
    Neue Ansätze zur Entwicklung von Modulatoren der homodimeren tRNA-Guanin-Transglycosylase

    Neue Ansätze zur Entwicklung von Modulatoren der homodimeren tRNA-Guanin-Transglycosylase door Nguyen, Andreas

    Gepubliceerd in 2020
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  5. 5
    Fragment-basierte Leitstruktursuche am Beispiel der Proteinkinase A

    Fragment-basierte Leitstruktursuche am Beispiel der Proteinkinase A door Oebbeke, Matthias

    Gepubliceerd in 2021
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  6. 6
    From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme

    From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme door Nguyen, Dzung

    Gepubliceerd in 2020
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  7. 7
    Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II

    Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II door Glöckner, Steffen

    Gepubliceerd in 2020
    Andere auteurs: “…Klebe, Gerhard Prof. Dr.…”
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  8. 8
    Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery.

    Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery. door Hassaan, Engi

    Gepubliceerd in 2019
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  9. 9
    Synthese von D-Phe/D-DiPhe-Pro-basierenden Liganden und deren biophysikalischen Charakterisierung zur Selektivitätsstudie von Thrombin und Trypsin sowie ein synthetischer Beitrag zur Darstellung von Inhibitoren der Aldose-Reduktase und Carboanhydrase II

    Synthese von D-Phe/D-DiPhe-Pro-basierenden Liganden und deren biophysikalischen Charakterisierung zur Selektivitätsstudie von Thrombin und Trypsin sowie ein synthetischer Beitrag z... door Ngo, Trong Khang

    Gepubliceerd in 2020
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  10. 10
    Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

    Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery door Petrick, Joy Kristin

    Gepubliceerd in 2019
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  11. 11
    Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery

    Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery door Münzker Lena

    Gepubliceerd in 2019
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  12. 12
    The Power of Fragments: FBLD approach to investigate protein structures

    The Power of Fragments: FBLD approach to investigate protein structures door Magari, Francesca

    Gepubliceerd in 2020
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  13. 13
    Identifizierung, Charakterisierung und Untersuchungen der Struktur-Wirkungs-Beziehung sowie des Mode of Action eines neuen antimikrobiellen Peptids aus Hirudo verbana

    Identifizierung, Charakterisierung und Untersuchungen der Struktur-Wirkungs-Beziehung sowie des Mode of Action eines neuen antimikrobiellen Peptids aus Hirudo verbana door Müller, Daniela

    Gepubliceerd in 2019
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr. rer. nat.)…”
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  14. 14
    Expanding the Toolbox for Computational Analysis in Rational Drug Discovery: Using Biomolecular Solvation to Predict Thermodynamic, Kinetic and Structural Properties of Protein-Ligand Complexes

    Expanding the Toolbox for Computational Analysis in Rational Drug Discovery: Using Biomolecular Solvation to Predict Thermodynamic, Kinetic and Structural Properties of Protein-Lig... door Hüfner, Tobias

    Gepubliceerd in 2019
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  15. 15
    Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin

    Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin door Cramer, Jonathan

    Gepubliceerd in 2017
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  16. 16
    Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography

    Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography door Siefker, Christof

    Gepubliceerd in 2018
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  17. 17
    Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

    Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques door Bertoletti, Nicole

    Gepubliceerd in 2017
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  18. 18
    Proteindynamik - Flexibilität in Zielproteinen des strukturbasierten Wirkstoffdesigns

    Proteindynamik - Flexibilität in Zielproteinen des strukturbasierten Wirkstoffdesigns door Terwesten, Felix

    Gepubliceerd in 2017
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  19. 19
    Erkennen von Proteinoberflächen durch ungewöhnliche Substrat-analoge Inhibitoren am Beispiel der cAMP-abhängigen Proteinkinase A

    Erkennen von Proteinoberflächen durch ungewöhnliche Substrat-analoge Inhibitoren am Beispiel der cAMP-abhängigen Proteinkinase A door Müller, Janis

    Gepubliceerd in 2017
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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  20. 20
    Systematic Correlation of Structural, Thermodynamic and Residual Solvation Properties of Hydrophobic Substituents in Hydrophobic Pockets Using Thermolysin as a Case Study

    Systematic Correlation of Structural, Thermodynamic and Residual Solvation Properties of Hydrophobic Substituents in Hydrophobic Pockets Using Thermolysin as a Case Study door Krimmer, Stefan Günter

    Gepubliceerd in 2017
    Andere auteurs: “…Klebe, Gerhard (Prof. Dr.)…”
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