Risultati della ricerca - Klebe, Gerhard (Prof. Dr.)

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  1. 1
    Leitstruktursuche mithilfe eines kristallographischen Fragment-Screenings zur Inhibierung des Klasse-II-Chaperons IpgC aus Shigella flexneri

    Leitstruktursuche mithilfe eines kristallographischen Fragment-Screenings zur Inhibierung des Klasse-II-Chaperons IpgC aus Shigella flexneri di Gárdonyi, Marina

    Pubblicazione 2021
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  2. 2
    Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

    Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase di Sandner, Anna Sophie

    Pubblicazione 2022
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  3. 3
    Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the Road of Drug Design

    Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the... di Badran, Mohammed

    Pubblicazione 2021
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  4. 4
    Neue Ansätze zur Entwicklung von Modulatoren der homodimeren tRNA-Guanin-Transglycosylase

    Neue Ansätze zur Entwicklung von Modulatoren der homodimeren tRNA-Guanin-Transglycosylase di Nguyen, Andreas

    Pubblicazione 2020
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  5. 5
    Fragment-basierte Leitstruktursuche am Beispiel der Proteinkinase A

    Fragment-basierte Leitstruktursuche am Beispiel der Proteinkinase A di Oebbeke, Matthias

    Pubblicazione 2021
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  6. 6
    From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme

    From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme di Nguyen, Dzung

    Pubblicazione 2020
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  7. 7
    Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II

    Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II di Glöckner, Steffen

    Pubblicazione 2020
    Altri autori: “...Klebe, Gerhard Prof. Dr....”
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  8. 8
    Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery.

    Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery. di Hassaan, Engi

    Pubblicazione 2019
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  9. 9
    Synthese von D-Phe/D-DiPhe-Pro-basierenden Liganden und deren biophysikalischen Charakterisierung zur Selektivitätsstudie von Thrombin und Trypsin sowie ein synthetischer Beitrag zur Darstellung von Inhibitoren der Aldose-Reduktase und Carboanhydrase II

    Synthese von D-Phe/D-DiPhe-Pro-basierenden Liganden und deren biophysikalischen Charakterisierung zur Selektivitätsstudie von Thrombin und Trypsin sowie ein synthetischer Beitrag z... di Ngo, Trong Khang

    Pubblicazione 2020
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  10. 10
    Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

    Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery di Petrick, Joy Kristin

    Pubblicazione 2019
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  11. 11
    Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery

    Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery di Münzker Lena

    Pubblicazione 2019
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  12. 12
    The Power of Fragments: FBLD approach to investigate protein structures

    The Power of Fragments: FBLD approach to investigate protein structures di Magari, Francesca

    Pubblicazione 2020
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  13. 13
    Identifizierung, Charakterisierung und Untersuchungen der Struktur-Wirkungs-Beziehung sowie des Mode of Action eines neuen antimikrobiellen Peptids aus Hirudo verbana

    Identifizierung, Charakterisierung und Untersuchungen der Struktur-Wirkungs-Beziehung sowie des Mode of Action eines neuen antimikrobiellen Peptids aus Hirudo verbana di Müller, Daniela

    Pubblicazione 2019
    Altri autori: “...Klebe, Gerhard (Prof. Dr. rer. nat.)...”
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  14. 14
    Expanding the Toolbox for Computational Analysis in Rational Drug Discovery: Using Biomolecular Solvation to Predict Thermodynamic, Kinetic and Structural Properties of Protein-Ligand Complexes

    Expanding the Toolbox for Computational Analysis in Rational Drug Discovery: Using Biomolecular Solvation to Predict Thermodynamic, Kinetic and Structural Properties of Protein-Lig... di Hüfner, Tobias

    Pubblicazione 2019
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  15. 15
    Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin

    Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin di Cramer, Jonathan

    Pubblicazione 2017
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  16. 16
    Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography

    Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography di Siefker, Christof

    Pubblicazione 2018
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  17. 17
    Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

    Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques di Bertoletti, Nicole

    Pubblicazione 2017
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  18. 18
    Proteindynamik - Flexibilität in Zielproteinen des strukturbasierten Wirkstoffdesigns

    Proteindynamik - Flexibilität in Zielproteinen des strukturbasierten Wirkstoffdesigns di Terwesten, Felix

    Pubblicazione 2017
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  19. 19
    Erkennen von Proteinoberflächen durch ungewöhnliche Substrat-analoge Inhibitoren am Beispiel der cAMP-abhängigen Proteinkinase A

    Erkennen von Proteinoberflächen durch ungewöhnliche Substrat-analoge Inhibitoren am Beispiel der cAMP-abhängigen Proteinkinase A di Müller, Janis

    Pubblicazione 2017
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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  20. 20
    Systematic Correlation of Structural, Thermodynamic and Residual Solvation Properties of Hydrophobic Substituents in Hydrophobic Pockets Using Thermolysin as a Case Study

    Systematic Correlation of Structural, Thermodynamic and Residual Solvation Properties of Hydrophobic Substituents in Hydrophobic Pockets Using Thermolysin as a Case Study di Krimmer, Stefan Günter

    Pubblicazione 2017
    Altri autori: “...Klebe, Gerhard (Prof. Dr.)...”
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