PublikationsserverSøgeresultater - Klebe, Gerhard (Prof. Dr.)
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1
Leitstruktursuche mithilfe eines kristallographischen Fragment-Screenings zur Inhibierung des Klasse-II-Chaperons IpgC aus Shigella flexneri
Udgivet 2021Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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2
Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase
Udgivet 2022Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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3
Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the...
Udgivet 2021Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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4
Neue Ansätze zur Entwicklung von Modulatoren der homodimeren tRNA-Guanin-Transglycosylase
Udgivet 2020Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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5
Fragment-basierte Leitstruktursuche am Beispiel der Proteinkinase A
Udgivet 2021Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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6
From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme
Udgivet 2020Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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7
Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II
Udgivet 2020Andre forfattere: “...Klebe, Gerhard Prof. Dr....”
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8
Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery.
Udgivet 2019Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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9
Synthese von D-Phe/D-DiPhe-Pro-basierenden Liganden und deren biophysikalischen Charakterisierung zur Selektivitätsstudie von Thrombin und Trypsin sowie ein synthetischer Beitrag z...
Udgivet 2020Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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10
Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery
Udgivet 2019Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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11
Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery
Udgivet 2019Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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12
The Power of Fragments: FBLD approach to investigate protein structures
Udgivet 2020Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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13
Identifizierung, Charakterisierung und Untersuchungen der Struktur-Wirkungs-Beziehung sowie des Mode of Action eines neuen antimikrobiellen Peptids aus Hirudo verbana
Udgivet 2019Andre forfattere: “...Klebe, Gerhard (Prof. Dr. rer. nat.)...”
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14
Expanding the Toolbox for Computational Analysis in Rational Drug Discovery: Using Biomolecular Solvation to Predict Thermodynamic, Kinetic and Structural Properties of Protein-Lig...
Udgivet 2019Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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15
Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin
Udgivet 2017Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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16
Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography
Udgivet 2018Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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17
Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques
Udgivet 2017Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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18
Proteindynamik - Flexibilität in Zielproteinen des strukturbasierten Wirkstoffdesigns
Udgivet 2017Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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19
Erkennen von Proteinoberflächen durch ungewöhnliche Substrat-analoge Inhibitoren am Beispiel der cAMP-abhängigen Proteinkinase A
Udgivet 2017Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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20
Systematic Correlation of Structural, Thermodynamic and Residual Solvation Properties of Hydrophobic Substituents in Hydrophobic Pockets Using Thermolysin as a Case Study
Udgivet 2017Andre forfattere: “...Klebe, Gerhard (Prof. Dr.)...”
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