Publikationsserver der Universitätsbibliothek Marburg

Titel:Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation
Autor:van Geffen, Chiel
Weitere Verfasser:Heiss, Constantin; Deißler, Astrid; Kolahian, Saeed
Veröffentlicht:2022
URI:https://archiv.ub.uni-marburg.de/es/2023/0141
DOI: https://doi.org/10.3389/fimmu.2022.933847
URN: urn:nbn:de:hebis:04-es2023-01416
DDC:610 Medizin
Publikationsdatum:2023-10-04
Lizenz:https://creativecommons.org/licenses/by/4.0

Dokument

Schlagwörter:
MDSC, immune suppression, pharmacotherapy, immunomodulation, inflammation

Summary:
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent suppressive and regulative properties. MDSCs’ strong immunosuppressive potential creates new possibilities to treat chronic inflammation and autoimmune diseases or induce tolerance towards transplantation. Here, we summarize and critically discuss different pharmacological approaches which modulate the generation, activation, and recruitment of MDSCs in vitro and in vivo, and their potential role in future immunosuppressive therapy.


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