Publikationsserver der Universitätsbibliothek Marburg
Titel:Die DAG/OAG-Sensitivität des TRPC5 in HEK293- und HT22-Zellen
Autor:Philipp, Maximilian
Weitere Beteiligte: Plant, Timothy (Prof. Dr.)
Veröffentlicht:2016
URI:https://archiv.ub.uni-marburg.de/diss/z2016/0545
DOI: https://doi.org/10.17192/z2016.0545
DDC: Medizin
Titel (trans.):The DAG/OAG sensitivity in HEK293 and HT22 cells
Publikationsdatum:2017-02-03
Lizenz:https://creativecommons.org/licenses/by-nc-sa/4.0

Dokument

Schlagwörter:
Proteinkinase C, PIP2, NHERF, NHERF, TRPC5, TRPC5, TRP, Ionenkanal, Proteinkinase C, TRP, PIP2

Zusammenfassung:
Der TRPC5 wird anders als bisher bekannt unter bestimmten Einflüssen durch DAG und sein Analogen OAG aktivierbar. Dabei spielen die Aktivität der Proteinkinase C sowie die Bindung an NHERF und das Vorhandensein von PIP2 eine Rolle. Die DAG-Sensitivität kann sowohl im heterologen Modell in HEK293-Zellen, als auch bei endogener Expression in HT22-Zellen gezeigt werden. Somit ist DAG der wahrscheinliche second messenger bei einer Rezeptoraktivierung des TRPC5.

Bibliographie / References

  1. Cosens, D. J., and A. Manning. 1969. "Abnormal electroretinogram from a Drosophila mutant." Nature 224 216:285-7.
  2. Li, H. S., X. Z. Xu, and C. Montell. 1999. "Activation of a TRPC3-dependent cation current through the neurotrophin BDNF." Neuron, 261-73.
  3. Kanki, H., M. Kinoshita, A. Akaike, M. Satoh, Y. Mori, and S. Kaneko. 2001. "Activation of inositol 1,4,5-trisphosphate receptor is essential for the opening of mouse TRP5 channels." Mol Pharmacol 60 5:989-98.
  4. Kim, J. Y., and D. Saffen. 2005. "Activation of M1 muscarinic acetylcholine receptors stimulates the formation of a multiprotein complex centered on TRPC6 channels." In J Biol Chem, 32035-47.
  5. Zhang, Z., J. Tang, S. Tikunova, J. D. Johnson, Z. Chen, N. Qin, A. Dietrich, E. Stefani, L. Birnbaumer, and M. X. Zhu. 2001. "Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain." Proc Natl Acad Sci U S A 98 6:3168-73.
  6. Lucas, P., K. Ukhanov, T. Leinders-Zufall, and F. Zufall. 2003. "A diacylglycerolgated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction." Neuron 40 (3):551-61.
  7. Philipp, S., A. Cavalie, M. Freichel, U. Wissenbach, S. Zimmer, C. Trost, A. Marquart, M. Murakami, and V. Flockerzi. 1996. "A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL." EMBO J 15 22:6166-71.
  8. Feske, S., Y. Gwack, M. Prakriya, S. Srikanth, S. H. Puppel, B. Tanasa, P. G. Hogan, R. S. Lewis, M. Daly, and A. Rao. 2006. "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function." Nature, 179- 85.
  9. Elbashir, S. M., J. Harborth, K. Weber, and T. Tuschl. 2002. "Analysis of gene function in somatic mammalian cells using small interfering RNAs." Methods, 199-213. United States: 2002 Elsevier Science.
  10. Kedei, N., T. Szabo, J. D. Lile, J. J. Treanor, Z. Olah, M. J. Iadarola, and P. M. Blumberg. 2001. "Analysis of the native quaternary structure of vanilloid receptor 1." J Biol Chem 276 30:28613-9.
  11. Saleh, S. N., A. P. Albert, C. M. Peppiatt, and W. A. Large. 2006. "Angiotensin II activates two cation conductances with distinct TRPC1 and TRPC6 channel properties in rabbit mesenteric artery myocytes." J Physiol, 479- 95. England.
  12. Flockerzi, V. 2007. "An introduction on TRP channels." Handb Exp Pharmacol 179:1-19.
  13. Philipp, S., J. Hambrecht, L. Braslavski, G. Schroth, M. Freichel, M. Murakami, A. Cavalié, and V. Flockerzi. 1998. "A novel capacitative calcium entry channel expressed in excitable cells." EMBO J. 17:4274-4282.
  14. Liao, Y., N. W. Plummer, M. D. George, J. Abramowitz, M. X. Zhu, and L. Birnbaumer. 2009. "A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry." In Proc Natl Acad Sci U S A, 3202-6.
  15. Tang, Y., J. Tang, Z. Chen, C. Trost, V. Flockerzi, M. Li, V. Ramesh, and M. X. Zhu. 2000. "Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF." J Biol Chem 275 48:37559-64.
  16. Edwards, F. A., A. Konnerth, B. Sakmann, and T. Takahashi. 1989. "A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system." Pflugers Arch 414 5:600-12.
  17. Montell, C., L. Birnbaumer, V. Flockerzi, R. J. Bindels, E. A. Bruford, M. J. Caterina, D. E. Clapham, C. Harteneck, S. Heller, D. Julius, I. Kojima, Y. Mori, R. Penner, D. Prawitt, A. M. Scharenberg, G. Schultz, N. Shimizu, and M. X. Zhu. 2002. "A unified nomenclature for the superfamily of TRP cation channels." Mol Cell 9 2:229-31.
  18. Clapham, D. E. 2007. "Calcium signaling." Cell, 1047-58. United States.
  19. Berridge, M. J., M. D. Bootman, and H. L. Roderick. 2003. "Calcium signalling: dynamics, homeostasis and remodelling." Nat Rev Mol Cell Biol, 517-29. England.
  20. Beech, D. J. 2007. "Canonical transient receptor potential 5." Handb Exp Pharmacol 179:109-23.
  21. Berridge, M.J. 1995. "Capacitative calcium entry." Biochemical Journal 312:1-11.
  22. Lintschinger, B., M. Balzer-Geldsetzer, T. Baskaran, W. F. Graier, C. Romanin, M. X. Zhu, and K. Groschner. 2000. "Coassembly of Trp1 and Trp3 proteins generates diacylglycerol- and Ca2+-sensitive cation channels." J Biol Chem, 27799-805.
  23. Trebak, M., G. S. Bird, R. R. McKay, and J. W. Putney, Jr. 2002. "Comparison of human TRPC3 channels in receptor-activated and store-operated modes. Differential sensitivity to channel blockers suggests fundamental differences in channel composition." J Biol Chem, 21617-23.
  24. Trebak, M., L. Lemonnier, W. I. DeHaven, B. J. Wedel, G. S. Bird, and J. W. Putney, Jr. 2009. "Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels." Pflugers Arch 457 4:757-69.
  25. Lemonnier, L., M. Trebak, and J. W. Putney, Jr. 2008. "Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate." Cell Calcium, 506-14.
  26. Cheng, K. T., H. L. Ong, X. Liu, and I. S. Ambudkar. 2013. "Contribution and regulation of TRPC channels in store-operated Ca2+ entry." Curr Top Membr 71:149-79.
  27. Munsch, T., M. Freichel, V. Flockerzi, and H. C. Pape. 2003. "Contribution of transient receptor potential channels to the control of GABA release from dendrites." Proc Natl Acad Sci U S A 100 26:16065-70.
  28. Vig, M., C. Peinelt, A. Beck, D. L. Koomoa, D. Rabah, M. Koblan-Huberson, S. Kraft, H. Turner, A. Fleig, R. Penner, and J. P. Kinet. 2006. "CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry." In Science, 1220-3.
  29. Zhu, M. H., M. Chae, H. J. Kim, Y. M. Lee, M. J. Kim, N. G. Jin, D. K. Yang, I. So, and K. W. Kim. 2005. "Desensitization of canonical transient receptor potential channel 5 by protein kinase C." Am J Physiol Cell Physiol, C591- 600. United States.
  30. Kalwa, Hermann. 2009. Die physiologische Funktion von TRPC6 in Endothelzellen und glatten Muskelzellen der Lunge. University of Marburg.
  31. Kepura, F. 2010. Die Rolle von TRPC1 in CA1-Neuronen des murinen Hippocampus. Doktorarbeit, Philipps-Universität Marburg.
  32. Hofmann, T., A.G. Obukhov, M. Schaefer, C. Harteneck, T. Gudermann, and G. Schultz. 1999. "Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol." Nature 397:259-263.
  33. Smyth, J. T., L. Lemonnier, G. Vazquez, G. S. Bird, and J. W. Putney, Jr. 2006. "Dissociation of regulated trafficking of TRPC3 channels to the plasma membrane from their activation by phospholipase C." J Biol Chem, 11712-20. United States.
  34. Elbashir, S. M., J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl. 2001. "Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells." Nature, 494-8.
  35. Riccio, A., Y. Li, J. Moon, K. S. Kim, K. S. Smith, U. Rudolph, S. Gapon, G. L. Yao, E. Tsvetkov, S. J. Rodig, A. Van't Veer, E. G. Meloni, W. A. Carlezon, Jr., V. Y. Bolshakov, and D. E. Clapham. 2009. "Essential role for TRPC5 in amygdala function and fear-related behavior." Cell, 761-72.
  36. Vazquez, G., B. J. Wedel, M. Trebak, G. St John Bird, and J. W. Putney, Jr. 2003. "Expression level of the canonical transient receptor potential 3 (TRPC3) channel determines its mechanism of activation." In J Biol Chem, 21649- 54. United States.
  37. Lee-Kwon, W., J. B. Wade, Z. Zhang, T. L. Pallone, and E. J. Weinman. 2005. "Expression of TRPC4 channel protein that interacts with NHERF-2 in rat descending vasa recta." Am J Physiol Cell Physiol 288 4:C942-9.
  38. Kiselyov, K., X. Xu, G. Mozhayeva, T. Kuo, I. Pessah, G. Mignery, X. Zhu, L. Birnbaumer, and S. Muallem. 1998. "Functional interaction between InsP3 receptors and store-operated channels." Nature 396:478-482.
  39. Liao, Y., C. Erxleben, J. Abramowitz, V. Flockerzi, M. X. Zhu, D. L. Armstrong, and L. Birnbaumer. 2008. "Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels." In Proc Natl Acad Sci U S A, 2895-900.
  40. Khvorova, A., A. Reynolds, and S. D. Jayasena. 2003. "Functional siRNAs and miRNAs exhibit strand bias." Cell, 209-16. United States.
  41. Dietrich, A., and T. Gudermann. 2007. "TRPC6." Handb Exp Pharmacol (179):125- 41.
  42. Cheng, W., C. Sun, and J. Zheng. 2010. "Heteromerization of TRP channel subunits: extending functional diversity." Protein Cell 1 9:802-10.
  43. Vazquez, G., J. P. Lievremont, J. Bird G. St, and J. W. Putney, Jr. 2001. "Human Trp3 forms both inositol trisphosphate receptor-dependent and receptor-independent store-operated cation channels in DT40 avian B lymphocytes." Proc Natl Acad Sci U S A 98 20:11777-82.
  44. Zeng, F., S. Z. Xu, P. K. Jackson, D. McHugh, B. Kumar, S. J. Fountain, and D. J. Beech. 2004. "Human TRPC5 channel activated by a multiplicity of signals in a single cell." Journal of Physiology 559 Pt 3:739-50.
  45. Hamill, O. P., A. Marty, E. Neher, B. Sakmann, and F. J. Sigworth. 1981. "Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches." Pflugers Arch 391 2:85-100.
  46. Morimoto, B. H., and D. E. Koshland, Jr. 1990. "Induction and expression of longand short-term neurosecretory potentiation in a neural cell line." In Neuron, 875-80.
  47. Kinoshita-Kawada, M., J. Tang, R. Xiao, S. Kaneko, J. K. Foskett, and M. X. Zhu. 2005. "Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes." Pflugers Arch 450 5:345-54.
  48. Clapham, D. E., D. Julius, C. Montell, and G. Schultz. 2005. "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels." Pharmacol Rev 57 4:427-50.
  49. Tomita, Y., S. Kaneko, M. Funayama, H. Kondo, M. Satoh, and A. Akaike. 1998. "Intracellular Ca2+ store-operated influx of Ca2+ through TRP-R, a rat homolog of TRP, expressed in Xenopus oocytes." Neurosci. Lett. 248:195- 198.
  50. Blair, NT, JS Kaczmarek, and DE Clapham. 2009. "Intracellular calcium strongly potentiates agonist-activated TRPC5 channels." J Gen Physiol 133 5:525- 46.
  51. Kim, M. T., B. J. Kim, J. H. Lee, S. C. Kwon, D. S. Yeon, D. K. Yang, I. So, and K. W. Kim. 2006. "Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells." In Am J Physiol Cell Physiol, C1031-40.
  52. Cavalie, A. 2007. "Ionic channels formed by TRPC4." Handb Exp Pharmacol (179):93-108.
  53. Otsuguro, K., J. Tang, Y. Tang, R. Xiao, M. Freichel, V. Tsvilovskyy, S. Ito, V. Flockerzi, M. X. Zhu, and A. V. Zholos. 2008. "Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate." In J Biol Chem, 10026-36.
  54. Whitehead, K. A., R. Langer, and D. G. Anderson. 2009. "Knocking down barriers: advances in siRNA delivery." In Nat Rev Drug Discov, 129-38. England.
  55. Jung, S., A. Mühle, M. Schaefer, R. Strotmann, G. Schultz, and T. D. Plant. 2003. "Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth." J Biol Chem 278 6:3562-71.
  56. Alberts, Bruce, Dennis Bray, and Karin Hopkin, eds. 2012. Lehrbuch der molekularen Zellbiologie. Vol. 4. Auflage: Wiley-VCH.
  57. Nilius, B., and V. Flockerzi. 2014. "Mammalian transient receptor potential (TRP) cation channels. Preface." Handb Exp Pharmacol 223:v - vi.
  58. Boulay, G., D. M. Brown, N. Qin, M. Jiang, A. Dietrich, M. X. Zhu, Z. Chen, M. Birnbaumer, K. Mikoshiba, and L. Birnbaumer. 1999. "Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry." Proc Natl Acad Sci U S A
  59. Okada, T., R. Inoue, K. Yamazaki, A. Maeda, T. Kurosaki, T. Yamakuni, I. Tanaka, S. Shimizu, K. Ikenaka, K. Imoto, and Y. Mori. 1999. "Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G proteincoupled receptor." J Biol Chem 274 39:27359-70.
  60. Montell, C., and G. M. Rubin. 1989. "Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction." Neuron 2 4:1313-23.
  61. Okada, T., S. Shimizu, M. Wakamori, A. Maeda, T. Kurosaki, N. Takada, K. Imoto, and Y. Mori. 1998. "Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain." J. Biol. Chem. 273:10279-10287.
  62. Sung, T. S., J. P. Jeon, B. J. Kim, C. Hong, S. Y. Kim, J. Kim, J. H. Jeon, H. J. Kim, C. K. Suh, S. J. Kim, and I. So. 2011. "Molecular determinants of PKAdependent inhibition of TRPC5 channel." Am J Physiol Cell Physiol 301 4:C823-32.
  63. Riccio, A., A. D. Medhurst, C. Mattei, R. E. Kelsell, A. R. Calver, A. D. Randall, C. D. Benham, and M. N. Pangalos. 2002. "mRNA distribution analysis of human TRPC family in CNS and peripheral tissues." Brain Res Mol Brain Res 109 1-2:95-104.
  64. Zhang, L., and D. Saffen. 2001. "Muscarinic acetylcholine receptor regulation of TRP6 Ca2+ channel isoforms. Molecular structures and functional characterization." J Biol Chem 276 16:13331-9.
  65. Trebak, M., N. Hempel, B. J. Wedel, J. T. Smyth, G. S. Bird, and J. W. Putney, Jr. 2005. "Negative regulation of TRPC3 channels by protein kinase Cmediated phosphorylation of serine 712." Mol Pharmacol, 558-63.
  66. Saleh, S. N., A. P. Albert, and W. A. Large. 2009. "Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes." J Physiol, 531-40. England.
  67. Vazquez, G., B. J. Wedel, B. T. Kawasaki, G. S. Bird, and J. W. Putney, Jr. 2004. "Obligatory role of Src kinase in the signaling mechanism for TRPC3 cation channels." J Biol Chem 279 39:40521-8.
  68. Numberger, M., and A. Draguhn. 1996. Patch-Clamp-Technik, Labor im Fokus. Heidelberg Berlin Oxford: Spektrum Akademischer Verlag GmbH.
  69. Aktories, Klaus. 2005. Pharmakologie und Toxikologie. Vol. 9. Auflage. Elsevier, München.
  70. Smith, D. P., R. Ranganathan, R. W. Hardy, J. Marx, T. Tsuchida, and C. S. Zuker. 1991. "Photoreceptor deactivation and retinal degeneration mediated by a photoreceptor-specific protein kinase C." Science 254 5037:1478-84.
  71. Ong, H. L., L. B. de Souza, K. T. Cheng, and I. S. Ambudkar. 2014. "Physiological functions and regulation of TRPC channels." Handb Exp Pharmacol 223:1005-34.
  72. Putney, J. W. 2005. "Physiological mechanisms of TRPC activation." Pflugers Arch 451 1:29-34.
  73. Schmidt, Robert, Florian Lang, and Manfred Heckmann, eds. 2010. Physiologie des Menschen. Vol. 31. Auflage: Springer Medizin Verlag Heidelberg.
  74. van Rossum, D. B., and R. L. Patterson. 2009. "PKC and PLA2: probing the complexities of the calcium network." Cell Calcium, 535-45. Netherlands.
  75. Tai, C., D. J. Hines, H. B. Choi, and B. A. MacVicar. 2011. "Plasma membrane insertion of TRPC5 channels contributes to the cholinergic plateau potential in hippocampal CA1 pyramidal neurons." Hippocampus 21 9:958-67.
  76. Fire, A., S. Xu, M. K. Montgomery, S. A. Kostas, S. E. Driver, and C. C. Mello. 1998. "Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans." Nature 391 6669:806-11.
  77. Bousquet, S. M., M. Monet, and G. Boulay. 2010. "Protein kinase C-dependent phosphorylation of transient receptor potential canonical 6 (TRPC6) on serine 448 causes channel inhibition." In J Biol Chem, 40534-43.
  78. Hardie, R. C., A. Peretz, E. Suss-Toby, A. Rom-Glas, S. A. Bishop, Z. Selinger, and B. Minke. 1993. "Protein kinase C is required for light adaptation in Drosophila photoreceptors." Nature 363 6430:634-7.
  79. Bezzerides, V. J., I. S. Ramsey, S. Kotecha, A. Greka, and D. E. Clapham. 2004. "Rapid vesicular translocation and insertion of TRP channels." Nat Cell Biol 6:702-720.
  80. Schaefer, M., T. D. Plant, A. G. Obukhov, T. Hofmann, T. Gudermann, and G. Schultz. 2000. "Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5." J Biol Chem 275 23:17517-26.
  81. Plant, T. D., and M. Schaefer. 2005. "Receptor-operated cation channels formed by TRPC4 and TRPC5." Naunyn Schmiedebergs Arch Pharmacol 371 4:266-76.
  82. Venkatachalam, K., F. Zheng, and D. L. Gill. 2003. "Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C." J Biol Chem 278 31:29031-40.
  83. Rohacs, T., and B. Nilius. 2007. "Regulation of transient receptor potential (TRP) channels by phosphoinositides." Pflugers Arch 455 1:157-68.
  84. Rey, O., S. H. Young, R. Papazyan, M. S. Shapiro, and E. Rozengurt. 2006. "Requirement of the TRPC1 cation channel in the generation of transient Ca2+ oscillations by the calcium-sensing receptor." J Biol Chem, 38730-7.
  85. Haasnoot, J., E. M. Westerhout, and B. Berkhout. 2007. "RNA interference against viruses: strike and counterstrike." Nat Biotechnol, 1435-43. United States.
  86. Flemming, P. K., A. M. Dedman, S. Z. Xu, J. Li, F. Zeng, J. Naylor, C. D. Benham, A. N. Bateson, K. Muraki, and D. J. Beech. 2006. "Sensing of lysophospholipids by TRPC5 calcium channel." J Biol Chem 281 8:4977- 82.
  87. Trebak, M., J. Bird G. St, R. R. McKay, L. Birnbaumer, and J. W. Putney, Jr. 2003. "Signaling mechanism for receptor-activated canonical transient receptor potential 3 (TRPC3) channels." J Biol Chem, 16244-52.
  88. Neher, E., and B. Sakmann. 1976. "Single-channel currents recorded from membrane of denervated frog muscle fibres." Nature 260 5554:799-802.
  89. Vaca, L. 2010. "SOCIC: the store-operated calcium influx complex." In Cell Calcium, 199-209. Netherlands: 2010 Elsevier Ltd.
  90. Caplen, N. J., S. Parrish, F. Imani, A. Fire, and R. A. Morgan. 2001. "Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems." Proc Natl Acad Sci U S A, 9742-7. United States.
  91. Boguslawska, D. M., B. Machnicka, A. Hryniewicz-Jankowska, and A. Czogalla. 2014. "Spectrin and phospholipids - the current picture of their fascinating interplay." Cell Mol Biol Lett 19 1:158-79
  92. Yamada, H., M. Wakamori, Y. Hara, Y. Takahashi, K. Konishi, K. Imoto, and Y. Mori. 2000. "Spontaneous single-channel activity of neuronal TRP5 channel recombinantly expressed in HEK293 cells." Neurosci Lett 285 2:111-4.
  93. Roos, J., P. J. DiGregorio, A. V. Yeromin, K. Ohlsen, M. Lioudyno, S. Zhang, O. Safrina, J. A. Kozak, S. L. Wagner, M. D. Cahalan, G. Velicelebi, and K. A. Stauderman. 2005. "STIM1, an essential and conserved component of store-operated Ca2+ channel function." J Cell Biol, 435-45.
  94. Liou, J., M. L. Kim, W. D. Heo, J. T. Jones, J. W. Myers, J. E. Ferrell, Jr., and T. Meyer. 2005. "STIM is a Ca2+ sensor essential for Ca2+-store-depletiontriggered Ca2+ influx." Curr Biol, 1235-41. England.
  95. Liao, M., E. Cao, D. Julius, and Y. Cheng. 2013. "Structure of the TRPV1 ion channel determined by electron cryo-microscopy." Nature 504 (7478):107-12.
  96. Hofmann, T., M. Schaefer, G. Schultz, and T. Gudermann. 2002. "Subunit composition of mammalian transient receptor potential channels in living cells." Proc Natl Acad Sci U S A 99 11:7461-6.
  97. Margrie, T. W., A. H. Meyer, A. Caputi, H. Monyer, M. T. Hasan, A. T. Schaefer, W. Denk, and M. Brecht. 2003. "Targeted whole-cell recordings in the mammalian brain in vivo." Neuron 39 6:911-8.
  98. Weinman, E. J., R. A. Hall, P. A. Friedman, L. Y. Liu-Chen, and S. Shenolikar. 2006. "The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases." Annu Rev Physiol 68:491-505.
  99. Vazquez, G., B. J. Wedel, O. Aziz, M. Trebak, and J. W. Putney, Jr. 2004. "The mammalian TRPC cation channels." In Biochim Biophys Acta, 21-36. Netherlands.
  100. Vannier, B., X. Zhu, D. Brown, and L. Birnbaumer. 1998. "The membrane topology if human transient receptor potential 3 as inferred from glycosylationscanning mutagensis and epitope immunocytochemistry." J. Biol. Chem. 273:8675-8679.
  101. Kiselyov, K., G. A. Mignery, M. X. Zhu, and S. Muallem. 1999. "The N-terminal domain of the IP3 receptor gates store-operated hTrp3 channels [In Process Citation]." Mol Cell 4 3:423-9.
  102. Mery, L., B. Strauss, J. F. Dufour, K. H. Krause, and M. Hoth. 2002. "The PDZinteracting domain of TRPC4 controls its localization and surface expression in HEK293 cells." J Cell Sci 115 Pt 17:3497-508.
  103. Odell, A. F., D. F. Van Helden, and J. L. Scott. 2008. "The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels." J Biol Chem 283 (7):4395-407.
  104. Nilius, B., and G. Owsianik. 2011. "The transient receptor potential family of ion channels." Genome Biol, 218.
  105. Inoue, R., T. Okada, H. Onoue, Y. Hara, S. Shimizu, S. Naitoh, Y. Ito, and Y. Mori. 2001. "The transient receptor potential protein homologue TRP6 is the essential component of vascular a1-adrenoceptor-activated Ca2+- permeable cation channel." Circ Res 88 3:325-32.
  106. Mio, K., T. Ogura, S. Kiyonaka, Y. Hiroaki, Y. Tanimura, Y. Fujiyoshi, Y. Mori, and C. Sato. 2007. "The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas." J Mol Biol, 373-83.
  107. Huber, A., P. Sander, M. Bahner, and R. Paulsen. 1998. "The TRP Ca2+ channel assembled in a signaling complex by the PDZ domain protein INAD is phosphorylated through the interaction with protein kinase C (ePKC)." In FEBS Lett, 317-22. Netherlands.
  108. Hardie, R. C., and B. Minke. 1992. "The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors." Neuron 8 4:643-51.
  109. Kunert-Keil, C., F. Bisping, J. Kruger, and H. Brinkmeier. 2006. "Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains." BMC Genomics, 159.
  110. Davare, M. A., D. A. Fortin, T. Saneyoshi, S. Nygaard, S. Kaech, G. Banker, T. R. Soderling, and G. A. Wayman. 2009. "Transient receptor potential canonical 5 channels activate Ca2+/calmodulin kinase Igamma to promote axon formation in hippocampal neurons." J Neurosci, 9794-808 Davis, JB, and P Maher. 1994. "Protein kinase C activation inhibits glutamateinduced cytotoxicity in a neuronal cell line." Brain Res 652 (1):169-73.
  111. Storch, U., A. L. Forst, M. Philipp, T. Gudermann, and M. Mederos y Schnitzler. 2012. "Transient receptor potential channel 1 (TRPC1) reduces calcium permeability in heteromeric channel complexes." J Biol Chem, 3530-40.
  112. Nilius, B., and G. Owsianik. 2010. "Transient receptor potential channelopathies." Pflugers Arch 460 2:437-50.
  113. Liu, X., W. Wang, B. B. Singh, T. Lockwich, J. Jadlowiec, B. O'Connell, R. Wellner, M. X. Zhu, and I. S. Ambudkar. 2000. "Trp1, a candidate protein for the store-operated Ca(2+) influx mechanism in salivary gland cells." J Biol Chem 275 5:3403-11.
  114. Wes, P. D., J. Chevesich, A. Jeromin, C. Rosenberg, G. Stetten, and C. Montell. 1995. "TRPC1, a human homolog of a Drosophila store-operated channel." Proc Natl Acad Sci U S A 92 21:9652-6.
  115. Strübing, C, G Krapivinsky, L Krapivinsky, and DE Clapham. 2001. "TRPC1 and TRPC5 form a novel cation channel in mammalian brain." Neuron 29 3:645-55.
  116. Rychkov, G., and G. J. Barritt. 2007. "TRPC1 Ca(2+)-permeable channels in animal cells." Handb Exp Pharmacol 179:23-52.
  117. Liu, X., B. B. Singh, and I. S. Ambudkar. 2003. "TRPC1 is required for functional store-operated Ca2+ channels. Role of acidic amino acid residues in the S5-S6 region." J Biol Chem, 11337-43.
  118. Yildirim, E., and L. Birnbaumer. 2007. "TRPC2: molecular biology and functional importance." Handb Exp Pharmacol (179):53-75.
  119. Eder, P., M. Poteser, and K. Groschner. 2007. "TRPC3: a multifunctional, poreforming signalling molecule." Handb Exp Pharmacol (179):77-92.
  120. Berg, A. P., N. Sen, and D. A. Bayliss. 2007. "TrpC3/C7 and Slo2.1 are molecular targets for metabotropic glutamate receptor signaling in rat striatal cholinergic interneurons." J Neurosci 27 33:8845-56.
  121. Hartmann, J., E. Dragicevic, H. Adelsberger, H. A. Henning, M. Sumser, J. Abramowitz, R. Blum, A. Dietrich, M. Freichel, V. Flockerzi, L. Birnbaumer, and A. Konnerth. 2008. "TRPC3 channels are required for synaptic transmission and motor coordination." Neuron 59 3:392-8.
  122. Freichel, M., V. Tsvilovskyy, and J. E. Camacho-Londono. 2014. "TRPC4- and TRPC4-containing channels." Handb Exp Pharmacol 222:85-128.
  123. Obukhov, A. G., and M. C. Nowycky. 2004. "TRPC5 activation kinetics are modulated by the scaffolding protein ezrin/radixin/moesin-binding phosphoprotein-50 (EBP50)." J Cell Physiol 201 (2):227-35.
  124. Lee, Y. M., B. J. Kim, H. J. Kim, D. K. Yang, M. H. Zhu, K. P. Lee, I. So, and K. W. Kim. 2003. "TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomach." Am J Physiol Gastrointest Liver Physiol 284 4:G604-16.
  125. He, Z., C. Jia, S. Feng, K. Zhou, Y. Tai, X. Bai, and Y. Wang. 2012. "TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIalpha in rat hippocampal neurons." J Neurosci, 9383-95.
  126. Obukhov, A. G., and M. C. Nowycky. 2008. "TRPC5 channels undergo changes in gating properties during the activation-deactivation cycle." J Cell Physiol 216 (1):162-71.
  127. Gross, S. A., G. A. Guzman, U. Wissenbach, S. E. Philipp, M. X. Zhu, D. Bruns, and A. Cavalie. 2009. "TRPC5 is a Ca2+-activated channel functionally coupled to Ca2+-selective ion channels." J Biol Chem 284 49:34423-32.
  128. Greka, A., B. Navarro, E. Oancea, A. Duggan, and D. E. Clapham. 2003. "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology." Nat Neurosci 6 8:837-45.
  129. Jung, S., R. Strotmann, G. Schultz, and T. D. Plant. 2002. "TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells." Am J Physiol Cell Physiol 282 2:C347-59.
  130. Soboloff, J., M. Spassova, T. Hewavitharana, L. P. He, P. Luncsford, W. Xu, K. Venkatachalam, D. van Rossum, R. L. Patterson, and D. L. Gill. 2007. "TRPC channels: integrators of multiple cellular signals." Handb Exp Pharmacol 179:575-91.
  131. Yan, Hai-Dun, Claudio Villalobos, and Rodrigo Andrade. 2009. "TRPC Channels Mediate a Muscarinic Receptor-Induced Afterdepolarization in Cerebral Cortex." J. Neurosci. 29 32:10038-10046.
  132. Venkatachalam, K., and C. Montell. 2007. "TRP channels." Annu Rev Biochem 76:387-417.
  133. Clapham, D. E. 2003. "TRP channels as cellular sensors." Nature 426 6966:517-24.
  134. Groschner, K., S. Hingel, B. Lintschinger, M. Balzer, C. Romanin, X. Zhu, and W. Schreibmayer. 1998. "Trp proteins form store-operated channels in human vascular endothelial cells." FEBS Lett. 437:101-106.
  135. Flockerzi, V., and B. Nilius. 2014. "TRPs: truly remarkable proteins." Handb Exp Pharmacol 222:1-12.
  136. Ren, Haoming. 2007. Untersuchung des Aktivierungsmechanismus von TRPC5. Diplomarbeit, Philipps-Universität Marburg.
  137. Montell, C. 1999. "Visual transduction in Drosophila." Annu Rev Cell Dev Biol 15:231-68.
  138. Storch, Forst A. L., Pardatscher F., Philipp M., Gregoritza M., Gudermann T., and Mederos y Schnitzler M. 2015, Zur Veröffentlichung eingereicht. NHERF dissociation from TRPC4/5 proteins is required for channel gating by diacylglycerol.

* Das Dokument ist im Internet frei zugänglich - Hinweise zu den Nutzungsrechten
© UB Marburg 1997 - 2025 Universitätsbibliothek Marburg