Zusammenfassung:
Die EDHF-Antwort ist neben NO und PGI2 der dritte Hauptweg der endothelvermittelten Vasodilatation und eine selektive Öffnung des KCa3.1 Kanals könnte den Ansatzpunkt für eine neue Strategie zur Blutdrucksenkung darstellen (Feletou & Vanhoutte 2006, Sankaranarayanan et al. 2009).
Im Speziellen wurde an A.c.c. von Wildtyp- (KCa3.1+/+) und Knockouttieren
(KCa3.1-/-) der Einfluss von SKA-31 auf die durch Azetyllcholin induzierte Vasodilatation untersucht. Ebenfalls war es Ziel zu überprüfen, ob SKA-31 einen Einfluss auf die durch Phenylephrin und hohe Kaliumkonzentration induzierte Vasokonstriktion hat.
Die Ergebnisse der Untersuchungen zeigen, dass SKA-31 die EDHF-vermittelte Vasodilatation deutlich potenziert und eine hohe Selektivität für den KCa 3.1 Kanal besitzt. Auf die glattmuskuläre Funktion bestand kein Einfluss.
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