Establishment of new experimental models of progressive prodromal Parkinson’s disease using viral-mediated overexpression of wild-type human α-synuclein in the substantia nigra compacta and the locus coeruleus in mice

Establishment of new experimental models of progressive prodromal Parkinson’s disease using viral-mediated overexpression of wild-type human α-synuclein in the substantia nigra compacta and the locus coeruleus in mice

Part 1. Summary Alpha-7-nicotine-acetylcholine-receptor (α7-nAChR) agonists modulate the cholinergic anti-inflammatory pathway to attenuate proinflammatory signals and reduce dopaminergic neuronal cell loss in toxin-induced experimental murine models of Parkinson’s disease (PD). However, no researc...

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Bibliographic Details
Main Author: Lee, Bolam
Contributors: Oertel, Wolfgang (Prof. Dr. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2019
Subjects:
α-Synuclein
Parkinsonkrankheit
Medizin
Medical sciences Medicine
Online Access:PDF Full Text
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