From Active-Site Mapping to Lead Discovery using Fragment-based Approaches on the Aspartic protease Endothiapepsin
The work focuses on the evaluation and comparison of different fragment-based approaches, for which purpose the model system Endothiapepsin (EP) has been used. The enzyme belongs to the family of aspartic proteases. We used the 361-entry in-house fragment library compiled with physico-chemical pro...
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Бусад зохиолчид: | |
Формат: | Dissertation |
Хэл сонгох: | англи |
Хэвлэсэн: |
Philipps-Universität Marburg
2016
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Нөхцлүүд: | |
Онлайн хандалт: | PDF-н бүрэн текст |
Шошгууд: |
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