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Development of new immunoassay platforms for rapid serological diagnosis of Lyme borreliosis
The presented work describes the development of new ligand-binding assay platforms for rapid serological diagnosis. 3-D polyethylene sinter bodies and monodisperse gold nanoparticles have been successfully employed as protein carriers, providing sensitive, selective and rapid serological diagnosis....
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| Format: | Doctoral Thesis |
| Language: | English |
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Philipps-Universität Marburg
2016
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| Online Access: | PDF Full Text |
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| Summary: | The presented work describes the development of new ligand-binding assay platforms for rapid serological diagnosis. 3-D polyethylene sinter bodies and monodisperse gold nanoparticles have been successfully employed as protein carriers, providing sensitive, selective and rapid serological diagnosis. Detection of anti-Borrelia antibodies in human sera samples was taken as a model in our work. Antibodies recognition either by visible observation or by spectroscopic measurements was easily practicable. All developed assays could be performed in a short time, 5-30 min, providing a suitable colorimetric point of care test. The established assays offer simple, rapid and reliable tools of analysis with minimal cost, which can be easily transferred to other infectious diseases. |
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| DOI: | 10.17192/z2016.0497 |