Interim Design Modifications in Time-to-Event Studies

Interim Design Modifications in Time-to-Event Studies

We propose a flexible method for interim design modifications in time-to-event studies. With this method, it is possible to inspect the data at any time during the course of the study, without the need for pre-specification of a learning phase, and to make certain types of design modifications depen...

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Bibliografiska uppgifter
Huvudupphovsman: Irle, Sebastian
Övriga upphovsmän: Schäfer, Helmut (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Materialtyp: Dissertation
Språk:engelska
Publicerad: Philipps-Universität Marburg 2012
Ämnen:
CRP principle
Logrank statistic
Adaptives Verfahren
Medizin
Adaptive design
Conditional rejection probability
Kontrollierte klinische Studie
Conditional distribution
Medical sciences Medicine
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Signum: urn:nbn:de:hebis:04-z2012-01444
Utgivningstid: 2012-02-16
Datum der Annahme: 2012-01-20
Downloads: 48 (2024), 53 (2023), 116 (2022), 151 (2021), 120 (2020), 199 (2019), 89 (2018)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
Länk till materialet: https://archiv.ub.uni-marburg.de/diss/z2012/0144
https://doi.org/10.17192/z2012.0144

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