Interim Design Modifications in Time-to-Event Studies

Interim Design Modifications in Time-to-Event Studies

We propose a flexible method for interim design modifications in time-to-event studies. With this method, it is possible to inspect the data at any time during the course of the study, without the need for pre-specification of a learning phase, and to make certain types of design modifications depen...

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Autor principal: Irle, Sebastian
Altres autors: Schäfer, Helmut (Prof. Dr.) (Assessor de tesis)
Format: Dissertation
Idioma:anglès
Publicat: Philipps-Universität Marburg 2012
Matèries:
CRP principle
Logrank statistic
Adaptives Verfahren
Medizin
Adaptive design
Conditional rejection probability
Kontrollierte klinische Studie
Conditional distribution
Medical sciences Medicine
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Signatura: urn:nbn:de:hebis:04-z2012-01444
Data de publicació: 2012-02-16
Datum der Annahme: 2012-01-20
Downloads: 46 (2024), 53 (2023), 116 (2022), 151 (2021), 120 (2020), 199 (2019), 89 (2018)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL d'accés: https://archiv.ub.uni-marburg.de/diss/z2012/0144
https://doi.org/10.17192/z2012.0144

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