Interferon regulatory factors 1 and 4 in T cell mediated immune modulation

Interferon regulatory factors 1 and 4 in T cell mediated immune modulation

The transcription factor interferon regulatory factor (IRF) 1 is essential for T helper cell 1 differentiation. Hereby, the respective Irf1 knockout mouse displays a severe immune defect and has an Th2 directed immune status per se. This effect is measurable by increased production of interleukin-4,...

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Bibliographic Details
Main Author: Mahiny, Azita Josefine
Contributors: Lohoff, Michael (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2011
Subjects:
Cre-lox
knockout mouse
IRF4
Biowissenschaften, Biologie
Knockout-Maus
T cells
IRF1
T Zellen
Life sciences
Online Access:PDF Full Text
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