Interferon regulatory factors 1 and 4 in T cell mediated immune modulation

Interferon regulatory factors 1 and 4 in T cell mediated immune modulation

The transcription factor interferon regulatory factor (IRF) 1 is essential for T helper cell 1 differentiation. Hereby, the respective Irf1 knockout mouse displays a severe immune defect and has an Th2 directed immune status per se. This effect is measurable by increased production of interleukin-4,...

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Autor principal: Mahiny, Azita Josefine
Altres autors: Lohoff, Michael (Prof. Dr.) (Assessor de tesis)
Format: Dissertation
Idioma:anglès
Publicat: Philipps-Universität Marburg 2011
Matèries:
Cre-lox
IRF1
IRF4
T Zellen
T cells
Biowissenschaften, Biologie
Knockout-Maus
knockout mouse
Life sciences
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