Pituitary adenylate cyclase-activating polypeptide mediates differential signaling through PAC1 receptor splice variants and activates non-canonical cAMP dependent gene induction in the nervous system - Implications for homeostatic stress-responding

Pituitary adenylate cyclase-activating polypeptide mediates differential signaling through PAC1 receptor splice variants and activates non-canonical cAMP dependent gene induction in the nervous system - Implications for homeostatic stress-responding

Pituitary adenylate cyclase-activating polypeptide (PACAP)-mediated activation of its G protein-coupled receptor PAC1 results in activation of the two G proteins Gs and Gq to alter second messenger generation and gene transcription in the nervous system, important for homeostatic responses to stress...

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Kaydedildi:
Detaylı Bibliyografya
Yazar: Holighaus, Yvonne
Diğer Yazarlar: Weihe, Eberhard (Prof. Dr.) (Tez danışmanı)
Materyal Türü: Dissertation
Dil:İngilizce
Baskı/Yayın Bilgisi: Philipps-Universität Marburg 2011
Konular:
PACAP
Nervensystem
Neuropeptide
G protein-coupled receptors
gene expression
neuropharmacology
signal transduction
G-Protein gekoppelte Rezeptoren
Neuropharmakologie
nervous system
Signaltransduktion
Naturwissenschaften
stress
neuropeptides
Genexpression
Stress
Natural sciences & mathematics
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