Fragment based Drug Discovery; Design and Validation of a Fragment Library; Computer-based Fragment Screening and Fragment-to-Lead Expansion

Craan, Tobias Friedrich

Fragment based Drug Discovery; Design and Validation of a Fragment Library; Computer-based Fragment Screening and Fragment-to-Lead Expansion

In recent years, fragment screening has become a popular approach to identify new lead structures. Fragments are usually defined by the Astex ‘rule of three’ (RO3). Surface Plasmon Resonance (SPR), Nuclear Magnetic Resonance spectroscopy (NMR), biochemical assays and X-ray crystallography are effici...

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Detalhes bibliográficos
Autor principal:	Craan, Tobias Friedrich
Outros Autores:	Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Formato:	Dissertation
Idioma:	inglês
Publicado em:	Philipps-Universität Marburg 2011
Assuntos:	FBLD Fragment Naturwissenschaften Fragmentbasierte Leitstrukturentwicklung Fragmentbibliotek Fragment library Natural sciences & mathematics
Acesso em linha:	Texto integral em PDF
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Fragment based Drug Discovery; Design and Validation of a Fragment Library; Computer-based Fragment Screening and Fragment-to-Lead Expansion

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