Fragment based Drug Discovery; Design and Validation of a Fragment Library; Computer-based Fragment Screening and Fragment-to-Lead Expansion

Craan, Tobias Friedrich

Fragment based Drug Discovery; Design and Validation of a Fragment Library; Computer-based Fragment Screening and Fragment-to-Lead Expansion

In recent years, fragment screening has become a popular approach to identify new lead structures. Fragments are usually defined by the Astex ‘rule of three’ (RO3). Surface Plasmon Resonance (SPR), Nuclear Magnetic Resonance spectroscopy (NMR), biochemical assays and X-ray crystallography are effici...

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Номзүйн дэлгэрэнгүй
Үндсэн зохиолч:	Craan, Tobias Friedrich
Бусад зохиолчид:	Klebe, Gerhard (Prof. Dr.) (Дипломын ажлын зөвлөх)
Формат:	Dissertation
Хэл сонгох:	англи
Хэвлэсэн:	Philipps-Universität Marburg 2011
Нөхцлүүд:	Fragment Fragmentbibliotek Naturwissenschaften Fragment library Fragmentbasierte Leitstrukturentwicklung FBLD Natural sciences & mathematics
Онлайн хандалт:	PDF-н бүрэн текст
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Fragment based Drug Discovery; Design and Validation of a Fragment Library; Computer-based Fragment Screening and Fragment-to-Lead Expansion

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