Fragment based Drug Discovery; Design and Validation of a Fragment Library; Computer-based Fragment Screening and Fragment-to-Lead Expansion

Fragment based Drug Discovery; Design and Validation of a Fragment Library; Computer-based Fragment Screening and Fragment-to-Lead Expansion

In recent years, fragment screening has become a popular approach to identify new lead structures. Fragments are usually defined by the Astex ‘rule of three’ (RO3). Surface Plasmon Resonance (SPR), Nuclear Magnetic Resonance spectroscopy (NMR), biochemical assays and X-ray crystallography are effici...

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Dettagli Bibliografici
Autore principale: Craan, Tobias Friedrich
Altri autori: Klebe, Gerhard (Prof. Dr.) (Relatore della tesi)
Natura: Dissertation
Lingua:inglese
Pubblicazione: Philipps-Universität Marburg 2011
Soggetti:
Fragment
Fragmentbibliotek
Naturwissenschaften
Fragment library
Fragmentbasierte Leitstrukturentwicklung
FBLD
Natural sciences & mathematics
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