Fragment based Drug Discovery; Design and Validation of a Fragment Library; Computer-based Fragment Screening and Fragment-to-Lead Expansion

Craan, Tobias Friedrich

Fragment based Drug Discovery; Design and Validation of a Fragment Library; Computer-based Fragment Screening and Fragment-to-Lead Expansion

In recent years, fragment screening has become a popular approach to identify new lead structures. Fragments are usually defined by the Astex ‘rule of three’ (RO3). Surface Plasmon Resonance (SPR), Nuclear Magnetic Resonance spectroscopy (NMR), biochemical assays and X-ray crystallography are effici...

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書誌詳細
第一著者:	Craan, Tobias Friedrich
その他の著者:	Klebe, Gerhard (Prof. Dr.) (論文の指導者)
フォーマット:	Dissertation
言語:	英語
出版事項:	Philipps-Universität Marburg 2011
主題:	FBLD Fragment Naturwissenschaften Fragmentbasierte Leitstrukturentwicklung Fragmentbibliotek Fragment library Natural sciences & mathematics
オンライン･アクセス:	PDFフルテキスト
タグ:	タグ追加タグなし, このレコードへの初めてのタグを付けませんか!

Fragment based Drug Discovery; Design and Validation of a Fragment Library; Computer-based Fragment Screening and Fragment-to-Lead Expansion

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