Analysis of a capsid-modified and conditionally replicating, oncolytic adenoviral vector as a novel treatment for human glioblastoma multiforme.

Analysis of a capsid-modified and conditionally replicating, oncolytic adenoviral vector as a novel treatment for human glioblastoma multiforme.

Glioblastoma multiforme (GBM) is the most aggressive brain tumor, and patients rarely survive for more than 2 years. Gene therapy may offer new treatment options and improve the prognosis for patients with GBM. Adenovirus-mediated gene therapy strategies for brain tumors have been limited by ineffic...

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Bibliographic Details
Main Author: Wohlfahrt, Martin E.
Contributors: Lingelbach, Klaus (Prof.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2010
Subjects:
TRAIL
Glioblastoma multiforme, TRAIL
Oncolysis
Adenovirus
Onkolyse
Glioblastom
Adenovirus 5
Naturwissenschaften
Natural sciences & mathematics
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Call Number: urn:nbn:de:hebis:04-z2010-06444
Publication Date: 2010-12-02
Source: A capsid-modified, conditionally replicating oncolytic adenovirus vector expressing TRAIL Leads to enhanced cancer cell killing in human glioblastoma models. Cancer Res. 2007 Sep 15;67(18):8783-90. PMID: 17875719
Date of Acceptance: 2010-07-08
Downloads: 40 (2024), 75 (2023), 100 (2022), 124 (2021), 72 (2020), 93 (2019), 48 (2018)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2010/0644
https://doi.org/10.17192/z2010.0644

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