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Therapeutic Effects of recombinant human Keratinocyte Growth Factor (rHuKGF) in anElastase-Induced Emphysema Model in the Mouse
Pulmonary emphysema is a major manifestation of chronic obstructive pulmonary disease (COPD), which is characterized by persistent inflammation and progressive alveolar destruction. Such destruction in the distal respiratory tract is thought to be irreversible. Despite promising initial experimen...
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| Format: | Dissertation |
| Langue: | anglais |
| Publié: |
Philipps-Universität Marburg
2010
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| Accès en ligne: | Texte intégral en PDF |
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| Résumé: | Pulmonary emphysema is a major manifestation of chronic obstructive pulmonary
disease (COPD), which is characterized by persistent inflammation and progressive
alveolar destruction. Such destruction in the distal respiratory tract is thought to be
irreversible. Despite promising initial experiments using all-trans retinoic acid (ATRA)
supplementation to reverse emphysema in rats, contradictory results were obtained
by others. A number of studies have shown that the instillation of recombinant human
keratinocyte growth factor (rHuKGF) into the lung protects animals from acute lung
injury and favourably influences alveolar maintenance and repair. The mechanism of
protection, however, is not completely understood.
This study aimed at investigating the potential of rHuKGF to induce alveolar
regeneration. Two sets of experiments were performed: 1) an in-vivo study to
evaluate the therapeutic effects of rHuKGF in the elastase-induced pulmonary
emphysema mouse model; 2) an in-vitro study to elucidate the basic molecular
mechanism underlying the therapeutic effect of rHuKGF. |
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| DOI: | 10.17192/z2010.0589 |