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Novel imantib resistance mechanisms in chronic myloid leukemia
In my research, I found that the compensatory activation of PI3K/AKT/mTor signaling pathway contributes early imatinib resistance in LAMA cell models. We also found that the auto/paracrine of GM-CSF by imatinib resistant leukemic cells confers to potent imatinib and nilotinib resistance. These findi...
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| Natura: | Dissertation |
| Lingua: | inglese |
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Philipps-Universität Marburg
2007
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| Accesso online: | PDF Full Text |
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