Characterization of Binding Pocket Flexibility of Aldose Reductase

Characterization of Binding Pocket Flexibility of Aldose Reductase

Aldose Reductase (AR) is the first enzyme of the 'sorbitol pathway'. It is an NADPH dependent enzyme and catalyzes the reduction of various aldehydes to the corresponding alcohols. Its binding pocket shows intrinsic flexibility which is mainly mediated by a small loop region. A specificity...

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Gorde:
Xehetasun bibliografikoak
Egile nagusia: Zentgraf, Matthias
Beste egile batzuk: Klebe, Gerhard (Prof. Dr.) (Tesi aholkularia)
Formatua: Dissertation
Hizkuntza:ingelesa
Argitaratua: Philipps-Universität Marburg 2006
Gaiak:
Aldose Reduktase
Computational chemistry
Docking
Molekulardesign
Molecular dynamics
Molekularbewegung
Chemie
Chemistry & allied sciences
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Aleari buruzko argibideak
Sailkapena: urn:nbn:de:hebis:04-z2006-08429
Argitaratze data: 2006-12-21
Datum der Annahme: 2006-11-16
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Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL sarbidea: https://archiv.ub.uni-marburg.de/diss/z2006/0842
https://doi.org/10.17192/z2006.0842

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