Characterization of Binding Pocket Flexibility of Aldose Reductase

Characterization of Binding Pocket Flexibility of Aldose Reductase

Aldose Reductase (AR) is the first enzyme of the 'sorbitol pathway'. It is an NADPH dependent enzyme and catalyzes the reduction of various aldehydes to the corresponding alcohols. Its binding pocket shows intrinsic flexibility which is mainly mediated by a small loop region. A specificity...

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Autor principal: Zentgraf, Matthias
Altres autors: Klebe, Gerhard (Prof. Dr.) (Assessor de tesis)
Format: Dissertation
Idioma:anglès
Publicat: Philipps-Universität Marburg 2006
Matèries:
Aldose Reduktase
Computational chemistry
Docking
Molekulardesign
Molecular dynamics
Molekularbewegung
Chemie
Chemistry & allied sciences
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Signatura: urn:nbn:de:hebis:04-z2006-08429
Data de publicació: 2006-12-21
Datum der Annahme: 2006-11-16
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Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL d'accés: https://archiv.ub.uni-marburg.de/diss/z2006/0842
https://doi.org/10.17192/z2006.0842

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