Structural and Functional Studies of tRNA-Guanine Transglycosylase: A putative Drug Target for Shigellosis Therapy

Structural and Functional Studies of tRNA-Guanine Transglycosylase: A putative Drug Target for Shigellosis Therapy

In this study structure-based drug design approaches for Zymomonas mobilis tRNA - guanine transglycosylase (TGT) are presented. In Shigella sp., the causative agent of bacterial shigellosis, TGT is involved in pathogenicity. Concerning the amino acid sequence, TGTs from both genera are highly h...

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Bibliografiska uppgifter
Huvudupphovsman: Stengl, Bernhard
Övriga upphovsmän: Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Materialtyp: Dissertation
Språk:engelska
Publicerad: Philipps-Universität Marburg 2006
Ämnen:
Strukturbasiertes Design
Basenaustausch
Aminoacyl-tRNS
Enzyminhibitor
Structure-based drug design
TGT
tRNA
Medizin
Shigella
Kristallstrukturanalyse
Zymomonas mobilis
Bakterienruhr
lin-Benzoguanin
Transglykosylase
Transglycosylase
Base exchange
Medical sciences Medicine
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