Investigation of the catalytic mechanism of RNase P: the role of divalent metal ions and functional groups important for catalysis

Investigation of the catalytic mechanism of RNase P: the role of divalent metal ions and functional groups important for catalysis

The ribonucleoprotein enzyme ribonuclease (RNase) P is an endonuclease that generates the mature 5' -ends of tRNA. Bacterial RNase P is composed of a large RNA subunit (P RNA) and a small protein (P protein). Studies with P RNA from E. coli and B. subtilis have implied a specific role for two o...

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Bibliographic Details
Main Author: Cuzic-Feltens, Simona-Daniela
Contributors: Hartmann, Roland K. (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2006
Subjects:
Catalytic mechanism
Chemische Reaktion / Katalyse
tRNA
RNase P
Medizin
Metal ions
Endonucleasen
Medical sciences Medicine
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