Publikationsserver der Universitätsbibliothek Marburg
Titel:RNA recognition in immune cells
Autor:von Thülen, Tina
Weitere Beteiligte: Bauer, Stefan (Prof. Dr.)
Veröffentlicht:2010
URI:https://archiv.ub.uni-marburg.de/diss/z2010/0460
URN: urn:nbn:de:hebis:04-z2010-04604
DOI: https://doi.org/10.17192/z2010.0460
DDC: Naturwissenschaften
Titel (trans.):RNA Erkennung in Immunzellen
Publikationsdatum:2010-08-02
Lizenz:https://rightsstatements.org/vocab/InC-NC/1.0/

Dokument

Schlagwörter:
innate immunity, toll-like-receptors, zytosolische Helikasen, Ribosomale RNS, Immunstimulation, Adjuvantien, Cathelizidine, Influenza-A-Virus, RNA Fragmente, cytosolic RNA sensors, interferons, Toll-like-Rezeptoren, cathelicidine, Interferon, Pankreatische Ribonuclease, angeborene Immunsystem

Summary:
RNA stellt einen Stimulus für das angeborene Immunsystem durch die Aktivierung der endosomalen TLRs (3, 7 und 8) oder der zytosolischen RNA Sensoren (RIG-I und MDA-5) dar. Die Erkennung von RNA resultiert in der Sekretion von Typ-I Interferonen und / oder proinflammatorischen Zytokinen. Fremd-RNA wird über das Vorhandensein von "Nicht-Selbst" Strukturen, wie gehäufte Nukleotidmodifikationen, doppelsträngige Konformation oder eine terminale 5- Triphosphategruppe, erkannt. Diese Unterscheidung zwischen Selbst- und Fremd-RNA verhindert eine permanente Typ-I Interferon Sekretion und somit Autoimmunerkrankungen. Jedoch ist nach wie vor wenig über die strukturellen Einzelheiten der RNA Erkennung bekannt. In dieser Arbeit wurde der Einfluss von RNA-Modifikationen und das immunstimulatorische Potential von RNA aus Influenza-infizierten Zellen, Selbst-RNA Fragmenten sowie von Cathelizidine/RNA Komplexen analysiert.

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