Systematic site-directed mutagenesis to characterize subunit interactions in E. coli asparaginase II, an enzyme

Systematic site-directed mutagenesis to characterize subunit interactions in E. coli asparaginase II, an enzyme

L-asparaginases (EC 3.5.1.1) catalyze the hydrolysis of L-asparagine to aspartic acid and ammonia. Asparaginases of bacterial origin have been used for over 40 years in the treatment of acute lymphatic leukemia (ALL). Asparaginase isoenzyme II from Escherichia coli (EcA2) is especially effective in...

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Autor principal: Verma, Shikha
Altres autors: Röhm, Klaus-Heinrich (Prof.) (Assessor de tesis)
Format: Dissertation
Idioma:anglès
Publicat: Philipps-Universität Marburg 2005
Matèries:
Differential scanning calorimetry
Fluorescence spectroscopy
Ortspezifische Mutagenese
Oligomere
Site-directed mutagenesis
Fluoreszenzspektroskopie
Asparaginase
Denaturieren
Medizin
Stability
Denaturation
Oligomers
Stabilität
CD
Medical sciences Medicine
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Signatura: urn:nbn:de:hebis:04-z2005-07051
Data de publicació: 2005-12-27
Datum der Annahme: 2005-11-24
Downloads: 38 (2024), 66 (2023), 37 (2022), 50 (2021), 290 (2020), 64 (2019), 26 (2018)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL d'accés: https://archiv.ub.uni-marburg.de/diss/z2005/0705
https://doi.org/10.17192/z2005.0705

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