Systematic site-directed mutagenesis to characterize subunit interactions in E. coli asparaginase II, an enzyme

Systematic site-directed mutagenesis to characterize subunit interactions in E. coli asparaginase II, an enzyme

L-asparaginases (EC 3.5.1.1) catalyze the hydrolysis of L-asparagine to aspartic acid and ammonia. Asparaginases of bacterial origin have been used for over 40 years in the treatment of acute lymphatic leukemia (ALL). Asparaginase isoenzyme II from Escherichia coli (EcA2) is especially effective in...

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Detalhes bibliográficos
Autor principal: Verma, Shikha
Outros Autores: Röhm, Klaus-Heinrich (Prof.) (BetreuerIn (Doktorarbeit))
Formato: Dissertation
Idioma:inglês
Publicado em: Philipps-Universität Marburg 2005
Assuntos:
Differential scanning calorimetry
Fluorescence spectroscopy
Ortspezifische Mutagenese
Oligomere
Site-directed mutagenesis
Fluoreszenzspektroskopie
Asparaginase
Denaturieren
Medizin
Stability
Denaturation
Oligomers
Stabilität
CD
Medical sciences Medicine
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Detalhes do Exemplar
Área/Cota: urn:nbn:de:hebis:04-z2005-07051
Publikationsdatum: 2005-12-27
Datum der Annahme: 2005-11-24
Downloads: 48 (2024), 66 (2023), 37 (2022), 50 (2021), 290 (2020), 64 (2019), 26 (2018)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
Zugangs-URL: https://archiv.ub.uni-marburg.de/diss/z2005/0705
https://doi.org/10.17192/z2005.0705

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