Systematic site-directed mutagenesis to characterize subunit interactions in E. coli asparaginase II, an enzyme

Systematic site-directed mutagenesis to characterize subunit interactions in E. coli asparaginase II, an enzyme

L-asparaginases (EC 3.5.1.1) catalyze the hydrolysis of L-asparagine to aspartic acid and ammonia. Asparaginases of bacterial origin have been used for over 40 years in the treatment of acute lymphatic leukemia (ALL). Asparaginase isoenzyme II from Escherichia coli (EcA2) is especially effective in...

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Bibliografische gegevens
Hoofdauteur: Verma, Shikha
Andere auteurs: Röhm, Klaus-Heinrich (Prof.) (Thesis begeleider)
Formaat: Dissertation
Taal:Engels
Gepubliceerd in: Philipps-Universität Marburg 2005
Onderwerpen:
Differential scanning calorimetry
Fluorescence spectroscopy
Ortspezifische Mutagenese
Oligomere
Site-directed mutagenesis
Fluoreszenzspektroskopie
Asparaginase
Denaturieren
Medizin
Stability
Denaturation
Oligomers
Stabilität
CD
Medical sciences Medicine
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Plaatsingsnummer: urn:nbn:de:hebis:04-z2005-07051
Publicatiedatum: 2005-12-27
Datum der Annahme: 2005-11-24
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Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL naar item: https://archiv.ub.uni-marburg.de/diss/z2005/0705
https://doi.org/10.17192/z2005.0705

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