Systematic site-directed mutagenesis to characterize subunit interactions in E. coli asparaginase II, an enzyme

Systematic site-directed mutagenesis to characterize subunit interactions in E. coli asparaginase II, an enzyme

L-asparaginases (EC 3.5.1.1) catalyze the hydrolysis of L-asparagine to aspartic acid and ammonia. Asparaginases of bacterial origin have been used for over 40 years in the treatment of acute lymphatic leukemia (ALL). Asparaginase isoenzyme II from Escherichia coli (EcA2) is especially effective in...

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Bibliographic Details
Main Author: Verma, Shikha
Contributors: Röhm, Klaus-Heinrich (Prof.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2005
Subjects:
Differential scanning calorimetry
Fluorescence spectroscopy
Ortspezifische Mutagenese
Oligomere
Site-directed mutagenesis
Fluoreszenzspektroskopie
Asparaginase
Denaturieren
Medizin
Stability
Denaturation
Oligomers
Stabilität
CD
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-z2005-07051
Publication Date: 2005-12-27
Date of Acceptance: 2005-11-24
Downloads: 49 (2024), 66 (2023), 37 (2022), 50 (2021), 290 (2020), 64 (2019), 26 (2018)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2005/0705
https://doi.org/10.17192/z2005.0705

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