Publikationsserver
Expression unf Funktion von Makrophagen Migrations-Inhibitions-Faktor in humanen Glioblastomzelllinien
Die Funktion des Makrophagen Migrations Inhibitions Faktor [MIF] wurde zuerst im Immunsystem beschrieben. Erst in den letzten Jahren wurde auch erkannt, dass MIF eine wichtige Rolle bei der Tumorentstehung und Tumorprogression spielt. Ausgehend von dem Befund einer erhöhten MIF Expression in Geweb...
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| Định dạng: | Dissertation |
| Ngôn ngữ: | Tiếng Đức |
| Được phát hành: |
Philipps-Universität Marburg
2005
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| Những chủ đề: | |
| Truy cập trực tuyến: | Bài toàn văn PDF |
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The cytokine macrophage migration inhibitory factor (MIF) has been identified as a factor in the developement and progression of cancer, besides its many functions in the immune system. This thesis analysis the expression and function of MIF in human glioblastoma cells. MIF is upregulated and secreted in response to angiogenetic stimuli eg. hypoxia and glucose withdrawl in the tumour cell culture. Targeting MIF by antisense strategy and blockade by antibodies results in a decreased proliferation and in reintroduction of conatct inhibition in the glioblastoma cells.