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Glucose-6-Phosphatase- Dehydrogenase activity as modulative association between Parkinson’s disease and periodontitis
The association between periodontitis (PD) and Parkinson’s disease (PK) is discussed due to the inflammatory component of neurodegenerative processes. PK severity and affected areas were determined using the following neuropsychological tests: Unified Parkinson’s Disease Rating Score (UPDRS) and...
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| Autoren: | , , , , , , , , , |
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| Format: | Artikel |
| Jezik: | angleščina |
| Izdano: |
Philipps-Universität Marburg
2024
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| Teme: | |
| Online dostop: | PDF-Volltext |
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| Izvleček: | The association between periodontitis (PD) and Parkinson’s disease (PK) is
discussed due to the inflammatory component of neurodegenerative
processes. PK severity and affected areas were determined using the following
neuropsychological tests: Unified Parkinson’s Disease Rating Score (UPDRS) and
Hoehn and Yahr; non-motoric symptoms by Non-Motor Symptoms Scale
(NMSS), and cognitive involvement by Mini-Mental State Examination (MMSE).
Neuroinflammation and the resulting Glucose-6-Phosphatase-Dehydrogenase
(G6PD) dysfunction are part of the pathophysiology of PK. This study aimed to
evaluate these associations in periodontal inflammation. Clinical data and saliva-,
serum-, and RNA-biobank samples of 50 well-characterized diametric patients
with PK and five age- and sex-matched neurologically healthy participants were
analyzed for G6PD function, periodontal pathogens (Aggregatibacter
actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia,
Treponema denticola, Prevotella intermedia, Campylobacter rectus,
Fusobacterium nucleatum, and Filifactor alocis), monocyte chemoattractant
protein (MCP) 1, and interleukin (IL) 1-beta. Regression analysis was used to
identify associations between clinical and behavioral data, and t-tests were used
to compare health and disease. Compared with PK, no pathogens and lower
inflammatory markers (p < 0.001) were detectible in healthy saliva and serum, PKseverity/
UPDRS interrelated with the occurrence of Prevotella intermedia in
serum as well as IL1-beta levels in serum and saliva (p = 0.006, 0.019, 0.034),
Hoehn and Yahr correlated with Porphyromonas gingivalis, Prevotella
intermedia, RNA IL1-beta regulation, serum, and saliva IL1-beta levels, with pvalues
of 0.038, 0.011, 0.008, <0.001, and 0.010, while MMSE was associated
with Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum,
serum MCP 1 levels, RNA IL1-beta regulation and G6PD serum activity (p =
0.036, 0.003, 0.045, <0.001, and 0.021). Cognitive and motor skills seem to be important as representative tests are associated with periodontal pathogens and
oral/general inflammation, wherein G6PD-saliva dysfunction might be involved. |
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| Opis knjige/članka: | Gefördert durch den Open-Access-Publikationsfonds der UB Marburg. |
| DOI: | 10.3389/fcimb.2024.1298546 |