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Verbal memory depends on structural hippocampal subfield volume
Objective: To investigate correlates in hippocampal subfield volume and verbal and visual memory function in patients with temporal lobe epilepsy (TLE), mild amnestic cognitive impairment (MCI) and heathy participants (HP). Methods: 50 right-handed participants were included in this study; 11 pat...
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| Asıl Yazarlar: | , , , , , , , |
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| Materyal Türü: | Makale |
| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
Philipps-Universität Marburg
2023
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| Konular: | |
| Online Erişim: | PDF Tam Metin |
| Etiketler: |
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| Özet: | Objective: To investigate correlates in hippocampal subfield volume and verbal
and visual memory function in patients with temporal lobe epilepsy (TLE), mild
amnestic cognitive impairment (MCI) and heathy participants (HP).
Methods: 50 right-handed participants were included in this study; 11 patients
with temporal lobe epilepsy (TLE), 18 patients with mild amnestic cognitive
impairment (MCI) and 21 healthy participants (HP). Verbal memory performance
was evaluated via the verbal memory test (VLMT) and visual memory performance
via the diagnosticum for cerebral damage (DCM). Hippocampal subfield volumes
of T1-weighted Magnetic Resonance Imaging (MRI) scans were computed with
FreeSurfer version 7.1. Stepwise correlation analyses were performed between
the left hippocampal subfield volumes and learning, free recall, consolidation
and recognition performance scores of the VLMT as well as between right
hippocampal subfield volumes and visual memory performance.
Results: The volume of the left subicular complex was highly correlated to
learning performance (β = 0.284; p = 0.042) and free recall performance in
the VLMT (β = 0.434; p = 0.001). The volume of the left CA3 subfield showed a
significant correlation to the consolidation performance in the VLMT (β = 0.378;
p = 0.006) and recognition performance in the VLMT (β = 0.290; p = 0.037). There
was no significant correlation identified between the right hippocampal subfields
and the visual memory performance.
Conclusion: The results of this study show verbal memory correlates with
hippocampal subfields and support the role of left subiculum and left CA2/CA3 in
verbal memory performance. |
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| Diğer Bilgileri: | Gefördert durch den Open-Access-Publikationsfonds der UB Marburg. |
| DOI: | 10.3389/fneur.2023.1209941 |