Dokument
| Titel: | Novel imantib resistance mechanisms in chronic myloid leukemia |
| Autor: | Wang, Ying |
| Weitere Beteiligte: | Neubauer, Andreas (Prof. Dr.) |
| Veröffentlicht: | 2007 |
| URI: | https://archiv.ub.uni-marburg.de/diss/z2007/0309 |
| DOI: | https://doi.org/10.17192/z2007.0309 |
| URN: | urn:nbn:de:hebis:04-z2007-03098 |
| DDC: | 610 Medizin |
| Publikationsdatum: | 2007-05-09 |
| Lizenz: | https://rightsstatements.org/vocab/InC-NC/1.0/ |
| Schlagwörter: |
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| GM-CSF, PI3K/Akt pathway, Imatinib resistance, Conditioned medium, Chronic myeloid leukaemia |
Summary:
In my research, I found that the compensatory activation of PI3K/AKT/mTor signaling pathway contributes early imatinib resistance in LAMA cell models. We also found that the auto/paracrine of GM-CSF by imatinib resistant leukemic cells confers to potent imatinib and nilotinib resistance. These findings may serve as a novel strategy to overcome disease resistance to imatinib.
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