Klinischer Status und krankheitsspezifische Lebensqualität von Patienten mit fortgeschrittenem Parkinson-Syndrom im Verlauf eines Jahres
Die Parkinson-Erkrankung ist eine fortschreitende neurodegenerative Krankheit, die mit einem zunehmenden Grad an Behinderung und Abhängigkeit einhergeht und für die bisher keine Heilungschance besteht. Aufgrund des demographischen Wandels mit einer Zunahme an älteren Menschen anteilig an der Gesamtb...
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Format: | Doctoral Thesis |
Language: | German |
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Philipps-Universität Marburg
2024
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Online Access: | PDF Full Text |
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Parkinson's disease is a progressive neurodegenerative disease that is associated with an increasing degree of disability and dependence and for which there is currently no cure. Due to demographic change with an increase in elderly people as a proportion of the total population, an increase in Parkinson's patients must also be expected in the coming years. Since medical care, especially in industrialized countries, offers good to very good treatment, the proportion of very advanced patients will also increase. The present work as part of the international, multicenter CLaSP study (Care for Late Stage Parkinson's Disease) investigates the health-related and disease-specific quality of life of patients with advanced Parkinson's disease within one year. Patients of both sexes with advanced Parkinson's disease (Hoehn & Yahr IV and V) and a disease duration of at least seven years will be included in the study. In addition to sociodemographic data, the severity of the disease and quality of life will be collected during the study. Data collection is done by face-to-face direct interview using various standardized internationally validated questionnaires. In the present study, patients recruited at the German centers are selected (n=228). Changes in quality of life are collected in comparison to the baseline value (T1) after one year (T3). The present work has shown that patients with advanced Parkinson's syndrome are restricted to a high degree in their everyday life and are increasingly dependent on help from relatives or professional care. Likewise, the question of the work can be cautiously affirmed: the quality of life decreases in the course of a year in advanced Parkinson's syndrome. This can be explained not only by the motor symptoms increasing in the advanced state, but mainly due to a variety of non-motor symptoms. It is precisely the non-motor symptoms, such as disturbances of drive, mood or increasing anxiety, that are responsible for an increasing restriction of health-related quality of life. However, these are not always an integral part of the holistic treatment of patients with Parkinson's disease. Several publications were able to prove these theses in the course of this work. Due to a lack of comparability between baseline and T3 examination with a very different number of data sets, we had to limit ourselves to a descriptive description. As the data collection of the CLaSP study in the area of follow-up is still partly ongoing, more meaningful results may still follow.