Decoding the TP53 mutome: CRISPR perspectives on functional diversity and therapeutic interventions

The key transcription factor p53 plays a crucial role in executing diverse tumor suppressive functions in human cells, as evidenced by the high prevalence of mutations in its encoding gene, TP53, across various cancer entities. Remarkably, TP53 mutations predominantly manifest as missense mutations,...

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Bibliographic Details

Main Author:	Funk, Julianne
Contributors:	Stiewe, Thorsten (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2024
Subjects:	Mutagenesis TP53 Cancer CRISPR Biowissenschaften, Biologie Deep Mutational Scan Life sciences
Online Access:	PDF Full Text
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