Elucidating the Role of IgA in Allergic Disease

Elucidating the Role of IgA in Allergic Disease

We uncover an inhibitory role for IgA in mast cell degranulation. We conclude that IgA serves as a regulator of mast cell degranulation, including anaphylaxis, providing a new therapeutic potential for IgE-mediated allergic disease. Additionally, through the development of mice deficient in IgA but...

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Bibliographic Details
Main Author: El Ansari, Yasmeen
Contributor: Institute of Laboratory Medicine, Boston Children's Hospital (Issuing body)
Contributors: Renz, Harald (Prof. Dr.) (Thesis advisor), Oettgen, Hans (Prof.Dr.)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2024
Subjects:
Atopie
IgA-Mangel
IgA
atopy
Allergie
IgA deficiency
Allgemeines, Wissenschaft
Allergy
Generalities, Science
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Call Number: urn:nbn:de:hebis:04-z2024-01807
Publication Date: 2024-05-27
Source: Yasmeen S. El Ansari, Cynthia Kanagaratham, Oliver T. Burton, Jenna V. Santos, Brianna-Marie A. Hollister, Owen L. Lewis, Harald Renz, and Hans C. Oettgen. Allergen-Specific IgA Antibodies Block IgE-Mediated Activation of Mast Cells and Basophils. Front Immunol. 2022 July 5. https://doi.org/10.3389/fimmu.2022.881655
Date of Acceptance: 2024-04-25
Downloads: 49 (2024)
License: https://creativecommons.org/licenses/by-sa/4.0
Access URL: https://archiv.ub.uni-marburg.de/diss/z2024/0180
https://doi.org/10.17192/z2024.0180

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