MAGED2 is essential for Gαs and cAMP/PKA signaling under hypoxia, which promotes induction of HIF-1α and inhibits stress-induced autophagy

MAGED2 mutations cause a severe but transient form of antenatal Bartter syndrome, known as transient Bartter syndrome (tBS or Bartter type 5). This condition is characterized by significant renal salt wasting in affected fetuses and newborns, resulting in pronounced fetal urine production and excess...

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Bibliographic Details

Main Author:	Nasrah, Sadiq (M.Sc.)
Contributors:	Kömhoff,Martin (Prof. Dr. ) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2024
Subjects:	Medizin PKA Bartter syndrome HIF-1α MAGED2 Gαs Stress-induced autophagy Bartter-Syndrom Biology Hypoxie cAMP Hypoxia Stress-induzierte Autophagie Medical sciences Medicine
Online Access:	PDF Full Text
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