MAGED2 is essential for Gαs and cAMP/PKA signaling under hypoxia, which promotes induction of HIF-1α and inhibits stress-induced autophagy

MAGED2 is essential for Gαs and cAMP/PKA signaling under hypoxia, which promotes induction of HIF-1α and inhibits stress-induced autophagy

MAGED2 mutations cause a severe but transient form of antenatal Bartter syndrome, known as transient Bartter syndrome (tBS or Bartter type 5). This condition is characterized by significant renal salt wasting in affected fetuses and newborns, resulting in pronounced fetal urine production and excess...

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Bibliographic Details
Main Author: Nasrah, Sadiq (M.Sc.)
Contributors: Kömhoff,Martin (Prof. Dr. ) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2024
Subjects:
Medizin
PKA
Bartter syndrome
HIF-1α
MAGED2
Gαs
Stress-induced autophagy
Bartter-Syndrom
Biology
Hypoxie
cAMP
Hypoxia
Stress-induzierte Autophagie
Medical sciences Medicine
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