The Rho GEF Trio is transported by microtubule plus-ends and involved in focal adhesion formation in migrating neural crest cells

Directed cell migration depends on cytoskeletal rearrangements, protrusion formation, cell contraction and focal adhesion turnover. These processes are regulated by spatiotemporal fine-tuning of Rho GTPase activity. The Rho guanine nucleotide exchange factor (GEF) Trio is well suited to control R...

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Bibliographic Details

Main Author:	Gossen, Stefanie
Contributors:	Borchers, Annette (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2023
Subjects:	microtubules focal adhesion dynamics focal adhesions microtubule dynamics cell migration neural crest cell migration neural crest cells Rho GEF Rho GEF Trio Allgemeines, Wissenschaft Generalities, Science
Online Access:	PDF Full Text
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