The multifaceted role of mutant p53 in remodeling the tumor transcriptome and secretome

The tumor suppressor gene TP53 is frequently inactivated by missense mutations in human cancers. These genetic alterations give rise to the expression of mutant variants of the encoded p53 protein (mutp53) that have lost their tumor-suppressive functions. Moreover, many mutp53 proteins acquire novel...

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Bibliographic Details
Main Author: Neumann, Michelle
Contributors: Stiewe, Thorsten (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2023
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Online Access:PDF Full Text
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