The multifaceted role of mutant p53 in remodeling the tumor transcriptome and secretome
The tumor suppressor gene TP53 is frequently inactivated by missense mutations in human cancers. These genetic alterations give rise to the expression of mutant variants of the encoded p53 protein (mutp53) that have lost their tumor-suppressive functions. Moreover, many mutp53 proteins acquire novel...
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Format: | Doctoral Thesis |
Language: | English |
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Philipps-Universität Marburg
2023
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Online Access: | PDF Full Text |
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