Characterization of the transcriptional repressor SAMD1 in hepatocellular carcinoma and pancreatic ductal adenocarcinoma

Until now, the protein SAMD1 had remained largely unexplored. However, recently, we identified SAMD1 as a novel CpG island-binding protein. SAMD1 directly interferes with unmethylated CpG-rich DNA via an atypical winged-helix domain, simultaneously engaging both the major and minor DNA groove. This...

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Bibliographic Details

Main Author:	Simon, Clara
Contributors:	Liefke, Robert (PD Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2023
Subjects:	cancer Chromatin Krebs Medizin SAMD1 HCC FBXO11 PDAC KDM1A Medical sciences Medicine
Online Access:	PDF Full Text
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