Characterization of the transcriptional repressor SAMD1 in hepatocellular carcinoma and pancreatic ductal adenocarcinoma

Characterization of the transcriptional repressor SAMD1 in hepatocellular carcinoma and pancreatic ductal adenocarcinoma

Until now, the protein SAMD1 had remained largely unexplored. However, recently, we identified SAMD1 as a novel CpG island-binding protein. SAMD1 directly interferes with unmethylated CpG-rich DNA via an atypical winged-helix domain, simultaneously engaging both the major and minor DNA groove. This...

Full description

Saved in:
Bibliographic Details
Main Author: Simon, Clara
Contributors: Liefke, Robert (PD Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2023
Subjects:
FBXO11
PDAC
HCC
Krebs
Medizin
cancer
Chromatin
SAMD1
KDM1A
Medical sciences Medicine
Online Access:PDF Full Text
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

PDF Full Text

Holdings details from
Call Number: urn:nbn:de:hebis:04-z2023-06001
Publication Date: 2023-11-27
Date of Acceptance: 2023-11-09
Downloads: 217 (2024), 32 (2023)
License: https://creativecommons.org/licenses/by-nc-sa/4.0
Access URL: https://archiv.ub.uni-marburg.de/diss/z2023/0600
https://doi.org/10.17192/z2023.0600

Similar Items