The role of IL-18 and IL-1 receptor signaling in T cell development and T cell exhaustion in a murine pancreatic cancer model

Pancreatic cancer is one of the deadliest cancer types and is characterized by a highly immunosuppressive tumor microenvironment. The abundance of T cells in the tumor microenvironment has been shown to improve the prognosis for pancreatic cancer patients. Nevertheless, T cell exhaustion can cause a...

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Bibliographic Details

Main Author:	Hellmund, Veronique
Contributors:	Bauer, Christian (PD Dr.), Buchholz, Malte (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2023
Subjects:	PDAC Exhaustion T-Zelle Medizin Medical sciences Medicine
Online Access:	PDF Full Text
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