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The role of IL-18 and IL-1 receptor signaling in T cell development and T cell exhaustion in a murine pancreatic cancer model

Pancreatic cancer is one of the deadliest cancer types and is characterized by a highly immunosuppressive tumor microenvironment. The abundance of T cells in the tumor microenvironment has been shown to improve the prognosis for pancreatic cancer patients. Nevertheless, T cell exhaustion can cause a...

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Main Author: Hellmund, Veronique
Contributors: Bauer, Christian (PD Dr.), Buchholz, Malte (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2023
Subjects:
PDAC
Exhaustion
T-Zelle
Medizin
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-z2023-05760
Publication Date: 2023-11-15
Date of Acceptance: 2023-10-04
Downloads: 79 (2025), 186 (2024), 7 (2023)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2023/0576
https://doi.org/10.17192/z2023.0576

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