The role of IL-18 and IL-1 receptor signaling in T cell development and T cell exhaustion in a murine pancreatic cancer model

Pancreatic cancer is one of the deadliest cancer types and is characterized by a highly immunosuppressive tumor microenvironment. The abundance of T cells in the tumor microenvironment has been shown to improve the prognosis for pancreatic cancer patients. Nevertheless, T cell exhaustion can cause a...

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Bibliographic Details
Main Author: Hellmund, Veronique
Contributors: Bauer, Christian (PD Dr.), Buchholz, Malte (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2023
Online Access:PDF Full Text
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