Characterization of single point mutation in the gamma-carboxyglutamic acid domain of recombinant clotting Factor IX and its therapeutic potential

Hemophilia B (HB) is an inherited bleeding disorder caused by deficiency of FIX. The severity is classified based on the FIX activity level in the plasma. The trough levels of FIX activity in the circulation above 5% is considered the relevant parameter to maintain hemostasis. Even though rFIX produ...

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Bibliographic Details

Main Author:	Knoll Machado, Steffi
Contributors:	Bacher, Michael (Professor) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2023
Subjects:	Medizin Faktor 9 Hemophilia B rekombinantes Protein , factor 9 Hämophilie B Gerinnungsfaktor IX Medical sciences Medicine
Online Access:	PDF Full Text
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