Elucidation of novel biosynthetic pathways for the discovery of cyclodipeptide derivatives from Streptomyces species

Cyclodipeptides (CDPs) with a 2,5-diketopiperazine (DKP) as central core occur ubiquitously in living organisms, from simple bacteria and fungi to more complex ones like plants and animals. They display various biological and pharmacological effects, including antibiotic, antifungal, and antiprolife...

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Bibliographic Details

Main Author:	Harken, Lauritz Christian
Contributors:	Li, Shu-Ming (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2022
Subjects:	Fe(II)/2-Oxoglutarate dependent Oxidas Sekundärmetabolit Cyclodipeptidoxidase Cyclodipeptide Oxidase Cyclodipeptidsynthase Cytochrom P-450 Natural Products Streptomyces Biosynthesis Biosynthese Cytochrome P450 Pharmakologie, Therapeutik Cyclodipeptide Synthase Fe(II)/2-Oxoglutarat abhängige Oxidase Pr Pharmacology & therapeutics, prescription drugs
Online Access:	PDF Full Text
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