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Investigations on the biosynthesis of secondary metabolites and biosynthetic enzymes from Aspergillus species

In this thesis, BGCs for secondary metabolites from A. ustus have been investigated via multiple approaches. The identified PKS-containing utt BGC and two similar NRPS-containing opa and opa2 BGCs from the same fungus A. ustus demonstrated clearly the large fungal potential for natural product produ...

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Bibliographic Details
Main Author: Zheng, Liujuan
Contributors: Li, Shu-Ming (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2021
Subjects:
Biowissenschaften, Biologie
nichtribosomalen Peptidsynthasen
Sekundärmetabolite
biosynthesis
Fungi
nonribosomal peptides
polyketides
Biosynthese
Pilzen
Polyketidsyntasen
secondary metabolites
Life sciences
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Summary:In this thesis, BGCs for secondary metabolites from A. ustus have been investigated via multiple approaches. The identified PKS-containing utt BGC and two similar NRPS-containing opa and opa2 BGCs from the same fungus A. ustus demonstrated clearly the large fungal potential for natural product production and new enzyme discovery. In addition, site-directed mutagenesis for a fungal PT led to the functional switching with enhanced conversion yields, indicating that site-directed mutagenesis is an effective tool to increase the structural diversity of natural products.
Physical Description:276 Pages
DOI:10.17192/z2021.0219

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